Grant-Funded Research
Research Papers are the results of OHE’s grant-funded research programmes intended to promote discussion and provide information prior to publication in a peer reviewed journal
What is the Normative Basis for Selecting the Measure of ‘Average’ Preferences for Use in Social Choices?
1 February 2017
The aim of this paper is to consider what normative arguments might exist for advocating the use of any given measure of the average in the…
An Analysis of NICE Technology Appraisal Decisions ‘Recommended in Line with Clinical Practice’
1 December 2016
This Research Paper explores decisions by the National Institute for Health and Care Excellence (NICE) that new technologies are to be recommended in line with clinical practice (RiLCP). The authors qualitatively assess documentation associated with RiLCP decisions to create a framework to describe common themes, and assess the level of patient access associated with each RiLCP decision.
Applying a Multi-criteria Decision Analysis (MCDA) Approach to Elicit Stakeholders’ Preferences in Italy. The Case of Obinutuzumab for Rituximab-Refractory Indolent Non-Hodgkin Lymphoma (iNHL)
1 December 2016
Published paper using MCDA to obtain preferences on decision criteria across three stakeholder groups (patients, clinicians and payers) in Italy and to assess the value of obinutuzumab for rituximab-refractory iNHL.
Extrapolation from Progression-Free Survival to Overall Survival in Oncology
1 December 2016
This Research Paper reports on a literature review of trials using PFS as a surrogate for OS in oncology between 2012 and 2016; a workshop and…
Important Aspects of Health Not Captured by EQ-5D: Views of the UK General Public
12 January 2016
This Research Paper reports the views of 179 members of the UK general public about important aspects of health that they consider to be missing from the five dimensions of the EQ-5D instrument.
Uncertainty and Risk in HTA Decision Making
1 November 2016
The quality of decision-making in key public sector bodies dealing with resource allocation is a major determinant of their efficiency. One of the most difficult and contentious areas of decision-making is the way that uncertainty is dealt with.
The Distribution of the EQ-5D-5L Index in Patient Populations
1 October 2016
EQ-5D data are often summarised by an EQ-5D index, whose distribution for its original version, the EQ-5D-3L, often shows two distinct groups in patient populations, arising…
A Review of NICE Methods Across Health Technology Assessment Programmes: Differences, Justifications and Implications
1 May 2016
NICE’s decisions exert an influence on the allocation of fixed NHS budgets, but decisions for different types of health interventions (for example drugs and devices) are…
New Methods for Modelling EQ-5D-5L Value Sets: An Application to English Data
1 January 2016
This paper provides details of how the EQ-5D-5L value set was derived, focusing on the methods used to model the stated preference data. Results for different…