Grant-Funded Research
Research Papers are the results of OHE’s grant-funded research programmes intended to promote discussion and provide information prior to publication in a peer reviewed journal
New Methods for Analysing the Distribution of EQ-5D Observations
1 April 2018
This paper reports new methods for analysing the distribution of EQ-5D observations. The Health State Density Index and Health State Density Curve are used to summarise…
Understanding the Context, Selecting the Standards: A Framework to Guide the Optimal Development and Use of Real-World Evidence for Coverage and Formulary Decisions
1 March 2018
OHE Research Paper 18/02: Real World Evidence (RWE) – This paper provides a framework and specific steps to help both manufacturers and payers meet the challenge…
Real World Evidence for Coverage Decisions: Opportunities and Challenges
3 January 2018
OHE Research Paper 18/01: This paper sets out the potential opportunities and important challenges and limitations that must be addressed in considering options for using RWE…
A New Valuation Method: Directly Eliciting Personal Utility Functions
1 August 2017
Standard methods for eliciting the preference data upon which value sets are based (e.g. time trade-off, standard gamble) generally have in common an aim to ‘uncover’ the…
Why Do Immigrants Report Lower Life Satisfaction?
1 July 2017
Questions of happiness and well-being have increasingly been drawing the attention of health economists, with the understanding that its measures approximate quality of life, or at…
‘Macro’ Evaluation of the NIHR Oxford Biomedical Research Centre
1 May 2017
The Oxford Biomedical Research Centre (BRC) was established in April 2007. OHE and RAND Europe were commissioned by the Oxford BRC to undertake a programme of…
Age and Utilities: Issues for HTA
1 April 2017
Several studies have found differences in health state values by age. We investigate whether and how age affects respondents’ Time Trade-Off (TTO) and Visual Analogue Scale…
Comparing the UK EQ-5D-3L and the English EQ-5D-5L Value Sets
1 March 2017
Three EQ-5D value sets (the EQ-5D-3L, crosswalk and EQ-5D-5L) are now available for cost utility analysis in the UK and/or England. The value sets’ characteristics differ,…
Gene Therapy: Understanding the Science, Assessing the Evidence, and Paying for Value
1 March 2017
This report presents an analysis of the significant clinical potential of gene therapy and the unique challenges in developing and evaluating evidence on their effectiveness and…