The World Health Organisation (WHO) has become quite skilled at promoting what changes are desirable in health care systems, and why, but has largely left how to implement those changes to individual countries. Although certainly no one solution will fit all countries, some evidence-informed guidelines and insights about how to implement change successfully may help ensure progress in large-scale health system transformation. To explore these issues concerning how to make policy stick and what needs to be in place for change to succeed, the WHO Regional Office for Europe launched health system transformation project in 2015 led by Bengoa and Hunter. Today’s seminar reviews the project’s progress to date.