• Biosimilars
  • Drug Development/R&D
  • All Topics
OHE OHE
Newsletter SignupSubscribe

News & Insights
  • News
  • Events
  • Insights
  • Bulletin
  • News
  • Events
  • Insights
  • Bulletin

News & Insights

  • News
  • Events
  • Insights
  • Bulletin
Newsletter SignupSubscribe
  • News
  • Events
  • Insights
  • Bulletin

Close
OHE OHE
  • Research & Publications
  • News & Insights
  • Education
  • Innovation Policy Prize
  • Events
  • About Us
  • OHE Experts
  • Contact Us
Newsletter SignupSubscribe

Research & Publications

All Publications

Filter by:
  • Antimicrobial Resistance (AMR)
  • Biosimilars
  • Cell and Gene Therapies
  • Chronic Diseases
  • Combination Therapies
  • COVID-19 Research
  • Digital Health
  • Drug Development/R&D
  • Emerging Markets
  • EQ-5D and PROMs
  • Health Care Systems
  • Health Data and Statistics
  • Health Technology Assessment
  • Precision Medicine
  • Real World Evidence
  • Use of Medicines
  • Value-Based Pricing
  • Vaccine Research
  • Economics of Innovation
  • Measuring and Valuing Outcomes
  • Policy, Organisation and Incentives in Health Systems
  • Value, Affordability and Decision Making

News & Insights

  • News
  • Events
  • Insights
  • Bulletin

Education

  • Education Hub
  • OHE Graduate School
  • EVIA Programme

Innovation Policy Prize

  • The Prize Fund
  • 2022 Prize Fund

Latest Research & Publications

Proposal for a General Outcome-based Value Attribution Framework for Combination Therapies

CombTher_Adobe_photoguns_portrait
Read more
© photoguns
  • Digital Health

Navigating the Landscape of Digital Health – United Kingdom

Healthcare_Adobe_elenabsl
Read more

2021 OHE Annual Report to the Charity Commission

charityreport_lina-trochez-unsplash_landscape
Read more
© Lina Trochez/Unsplash

Supporting the Era of Green Pharmaceuticals in the UK

Sustainability_AdobeStock_270582392_landscape
Read more

Quality of life and wellbeing in individuals with experience of fertility problems and assisted reproductive techniques

Quality of life assisted reproduction Cover
Read more
  • Cell and Gene Therapies
  • Value, Affordability, and…

Health Technology Assessment of Gene Therapies: Are Our Methods Fit for Purpose?

gene_therapies_national-cancer-institute-unsplash_landscape
Read more
© NCI/Unsplash
  • Drug Development/R&D
  • Economics of Innovation
  • Health Policy and Regulation

Limitations of CBO’s Simulation Model of New Drug Development as a Tool for Policymakers

CBO-US_mayer-tawfik-K4Ckc0AxgDI-unsplash_landscape
Read more
© Mayer Tawfik/Unsplash
  • Measuring and Valuing Outcomes

When Generic Measures Fail to Reflect What Matters to Patients: Three Case Studies

PROMS_unsplash_National Cancer Institute_landscape
Read more
© NCI/Unsplash
Close
OHE
  • All Publications

    Filter by:
    • Antimicrobial Resistance (AMR)
    • Biosimilars
    • Cell and Gene Therapies
    • Chronic Diseases
    • Combination Therapies
    • COVID-19 Research
    • Digital Health
    • Drug Development/R&D
    • Emerging Markets
    • EQ-5D and PROMs
    • Health Care Systems
    • Health Data and Statistics
    • Health Technology Assessment
    • Precision Medicine
    • Real World Evidence
    • Use of Medicines
    • Value-Based Pricing
    • Vaccine Research
    • Economics of Innovation
    • Measuring and Valuing Outcomes
    • Policy, Organisation and Incentives in Health Systems
    • Value, Affordability and Decision Making
    • News
    • Events
    • Insights
    • Bulletin
    • Education Hub
    • OHE Graduate School
    • EVIA Programme
    • The Prize Fund
    • 2022 Prize Fund
  • Events
  • About Us
  • OHE Experts
  • Contact Us
Newsletter SignupSubscribe
Back
  • News
11 min read 4th January 2017

Comparing the Cancer-Specific EORTC-8D and the Generic EQ-5D-3L

This early view paper published in Quality of Life Research compares a condition-specific preference based measure to a generic measure in a population of cancer patients. There is a wealth of literature that questions the sensitivity of generic preference-based measures…

Share:
  •  Twitter
  •  LinkedIn
  •  Facebook
  • has-icon Email

This early view paper published in Quality of Life Research compares a condition-specific preference based measure to a generic measure in a population of cancer patients.

There is a wealth of literature that questions the sensitivity of generic preference-based measures (PBMs) of health. To address this a number of condition-specific PBMs have been developed, although to date their use in decision-making is limited. If CSPBMs are to be more widely adopted, then evidence of their performance is required. In this recently published open access paper OHE’s Paula Lorgelly (with colleagues from Cambridge and Sheffield) assess the validity, responsiveness and sensitivity of a cancer-specific preference-based measure, the EORTC-8D, relative to the generic PBM, the EQ-5D-3L.

The analysis utilises Cancer 2015 a large-scale prospective longitudinal population-based molecular cancer cohort study from Victoria, Australia. In addition to clinical data and patient socio-demographics and familial history and participants self-completed patient reported outcome measures (PROMs) at baseline and various follow-up points depending on how advanced the cancer was. The PROMs included the EORTC QLQ-C30 which gives EORTC-8D values and the EQ-5D-3L. The analysis of baseline values used a complete case sample of 1678 patients; while 1157 patients had at least one follow-up point (some had up to five follow-ups) for whom QALYs were estimated.  The average follow-up was 434 days, the longest follow-up (in this slice of the dataset) was 1146 days.

Descriptive analysis found that the mean baseline health state value for the EORTC-8D was higher (0.829) than for the EQ-5D-3L (0.748). This may be a function of the EORTC-8D having a higher ‘floor’, and the lowest possible health state value is 0.292 compared with the EQ-5D-3L floor of -0.594. The assessment of convergent validity found that the various dimensions in each instrument and instrument scores were strongly correlated, while the analysis of content validity found few ceiling effects. Despite this, the agreement between the instruments was poor, with considerable variation in values for those with lower baseline health related quality of life.

The condition-specific QALYs estimated using the EORTC-8D were significantly higher (0.909) than those derived from the EQ-5D-3L over time (0.860) although the difference was small (0.049, p<0.001). Both the generic and condition-specific QALYs were found to be similarly sensitive to a number of patient and disease characteristics. When specifically considering the difference in QALYs (condition-specific minus generic QALY estimates) multivariate regression analysis found that the variation in baseline health state values had a large influence on the difference in QALYs.

The research team concluded that given the variability in sensitivity between the baseline values and the QALY estimations means researchers and decision makers are advised to be cautious if using the instruments interchangeably.  The marginally higher QALY estimates may be appealing but further research is required to confirm if these higher estimates offer a more accurate reflection of health related quality of life gains.

Reference:

Lorgelly, P.K., Doble, B., Rowen, D. Brazier, J., 2016. Condition-specific or generic preference-based measures in oncology? A comparison of the EORTC-8D and the EQ-5D-3L. Quality of Life Research. 

  • EQ-5D and PROMs
  • Measuring and Valuing Outcomes
  • External Publications

Related News

  • News
  • September 2020

Establishing a Reasonable Price for an Orphan Drug

Read more
  • News
  • April 2020

Augmenting Cost-Effectiveness Analysis for Uncertainty: The Implications for Value Assessment—Rationale and Empirical Support

Read more
  • News
  • April 2020

Financing and Scaling Innovation for the COVID Fight: A Closer Look at Demand-Side Incentives for a Vaccine

Read more
  • News
  • February 2020

Unpacking the Black Box of Payer Policy: A Demand-Side Approach for Equitable Uptake of Cost-Effective Health Innovation

Read more
footer_ohe_logo

Leading intellectual authority on global health economics

Sign Up for the OHE News Bulletin

Newsletter SignupStart Sign Up

Research & Publications

News & Insights

Innovation Policy Prize

Education

Events

About Us

OHE Experts

Contact Us

Sign Up for the OHE News Bulletin

Newsletter SignupStart Sign Up

The Office of Health Economics (OHE) is a company limited by guarantee registered in England and Wales (registered number 09848965) and its registered office is at 2nd Floor Goldings House, Hay’s Galleria, 2 Hay’s Lane, London, SE1 2HB.

Terms & Conditions

Privacy Policy

Cookies Policy

© 2023 Website Design

An error has occurred, please try again later.An error has occurred, please try again later.

We are using cookies to give you the best experience on our website.

You can find out more about which cookies we are using or switch them off in settings.

 Twitter
 Facebook
 LinkedIn
 Copy
 Email
Powered by  GDPR Cookie Compliance
Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.

Strictly Necessary Cookies

Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings.

If you disable this cookie, we will not be able to save your preferences. This means that every time you visit this website you will need to enable or disable cookies again.

3rd Party Cookies

This website uses Google Analytics to collect anonymous information such as the number of visitors to the site, and the most popular pages.

Keeping this cookie enabled helps us to improve our website.

Please enable Strictly Necessary Cookies first so that we can save your preferences!