Dakin, H., Devlin, N., Feng, Y., Rice, N., O'Neill, P. and Parkin, D.
In this Research Paper, the authors explore which factors have most influenced NICE decisions from 1999 through the end of 2011. The research has two objectives: identifying the influence of cost-effectiveness and other factors on NICE decisions, and investigating whether NICE’s decision making has changed over time.
This publication provides both up-to-date statistics and a guide to finding and using health statistics from the UK and, to some extent, other OECD countries. Data are presented in easy-to-read tables and figures.
The OHE Guide helps answer these important questions:
Since the second edition of this publication appeared in 2002, economic evaluation of new medical technologies as a basis for decisions about their use has expanded to an increasing number of countries and types of technology. At the same time, the methods themselves have evolved in response to experience and to changes in the ability to capture and analyse data.
Significantly increases of wealth and health in the Western world over the past 50 years do not appear to have produced an equivalent increase in societal happiness, at least not using traditional measures. As a result, policy makers now are looking more closely at alternative ways of measuring the welfare of society, including measures of subjective well-being.
Based on OHE’s 50th anniversary conference, this publication captures the views of thought leaders from around the world about the scientific and economic climate for drug development by 2022.
Four major themes stood out in the conference discussions, as reported in this publication.
1. Health care will be radically transformed as “precision” medicine plugs into the specific genetic makeup of both patients and diseases, and is paired with increasingly powerful and convenient diagnostics.
In this monograph based his remarks at the 19th OHE Annual Lecture, Professor Sir Michael Rawlins examines the standards of proof required to show the effectiveness of a medical therapy. He traces the historical development of inductive and deductive approaches in science, discussing the strengths and weaknesses of each.
Sir Michael expresses concern that some view randomised controlled trials (RCTs) as the “gold standard” of evidence. RCTs, he argues, are very important, but other approaches to evidence development can prove equally valid in some circumstances.
Sussex, J., Rollet, P., Garau, M., Schmitt, C., Kent, A. and Hutchings, A.
The purpose of this research is to identify the attributes to include in a value framework for orphan medicinal products (OMPs), determine their relative importance using a multi-criteria decision analysis (MCDA) process, and test whether an MCDA approach can support decision making in practice.
O’Neill, P., Mestre-Ferrandiz, J., Puig-Peiro, R. and Sussex, J.
Medicines account for less than 10% of total NHS expenditure in the UK. Because spending on medicines is easy to separate out, however, this sector continues to come under particular scrutiny in efforts to manage costs. Forecasting spending on medicines can be useful in planning NHS resource allocation. Simple extrapolations of past trends in medicines expenditure, however, are insufficient because they cannot account for shifts in the mix of medicines available on the market or the appearance of generics.