Adaptive Pathways: Generating Evidence of Value



Adaptive pathways promise a "triple win”. They enable early access for patients to the most promising innovative therapies, address concerns over affordability, cost-effectiveness and outcome uncertainty for payers, whilst meeting companies’ need to make R&D sustainable.

Yet uncertainty remains on when adaptive pathways are superior to traditional market entry routes, how to realise all of the potential benefits and how to overcome the challenges surrounding real world evidence generation.

This Masterclass addresses these strategic issues, shedding light on when adaptive pathways are optimal for innovative therapies, as well as bringing together multiple perspectives on these iterative pathways.

Participants will benefit from engaging with OHE’s global thought leaders, and from industry insights on successful examples of adaptive pathways applications, which have aligned regulatory and reimbursement evidentiary requirements to enable timely access to breakthrough therapies.

The Masterclass speakers will also reflect on the practical opportunities and potential barriers to the acceptability of real-world evidence, and will present optimal evidence generation plans for different treatment types.


Demonstrating Value: evolving with innovation explores this lively technical and policy debate where the evolving and sometimes challenging nature of innovative interventions is not always matched by value assessment paradigms applied by country decision makers.

Value assessments are necessary to ensure that healthcare expenditure is optimal but there is a need for a common understanding of what constitutes value, capturing what matters most to patients, society, and payers. The 2020 Masterclass Series will take attendees through the journey of exploring value from different perspectives and providing tools to identify consolidated and novel sources of value, and generate compelling evidence at different stages of the product life-cycle to demonstrate them.

Other Masterclasses in the Series

Exploring value: novel elements for breakthrough treatments

Patient preferences: what do patients value?

Innovation for small populations: what should we pay for?


100% of previous attendees said that they would recommend our Masterclass events – here’s what they’ve said:

“Excellent exploration of a complex issue, with good balance of the theory and the practice.”

“Overall a well-rounded course. The course provided an in-depth understanding of the challenge ahead of curative medicines."

"Highlighted all of the challenges and the various viewpoints. A realistic view of current and emerging situation."

“Very comprehensive deep dive into the issues and reason for OHE recommendations.”

“A very helpful event with some very high level experts covering subjects which could be difficult and contentious. Light into informational darkness.”


Each event in our Masterclass Series provides a highly collaborative space guided by candid expert perspectives. During the event we encourage open discussion of the topic, and believe that through this we have the potential to unlock transformative insight and reveal solutions to the challenges we face every day.

As the world’s oldest and most well-respected health economic research institute, we’re uniquely placed to bring you the latest in research, expertise and real-world evidence, as well as first-hand advice from global thought leaders. Together we can improve decisions surrounding healthcare, and deliver better outcomes for patients, payers and industry.

Click here for registration

Thursday, 5 November 2020